A Simple Catalytic Method for the Conversion of Aryl Bromides to Arylamines


  • This work was supported by the National Science Foundation (CHE-9000482) and the National Institutes of Health (GM34917). Additional support from the Dow Chemical Company is gratefully acknowledged. A. S. G. and R. A. R. were NCI Postdoctoral Trainees supported by NIH Cancer Training Grant CI T32CA09112. We thank Professor G. C. Fu for helpful discussions.


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A facile Pd-catalyzed method for the preparation of a wide variety of aryl amines from aryl bromides and amines has been developed [Eq. (a)]. Noteworthy features of this method include the experimental simplicity, the tin/boron-free conditions, and the broad spectrum of potential substrates.