Macrobicyclic Titanium(IV) Complexes with C3-Symmetric Synthetic Peptides

Authors

  • Dipl.-Chem. Kay Severin,

    1. Institut für Anorganische Chemie der Universität, Meiserstrasse 1, D-80333 München (Germany). Telefax: Int code + (89) 5902 451
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  • Prof. Dr. Wolfgang Beck,

    Corresponding author
    1. Institut für Anorganische Chemie der Universität, Meiserstrasse 1, D-80333 München (Germany). Telefax: Int code + (89) 5902 451
    • Institut für Anorganische Chemie der Universität, Meiserstrasse 1, D-80333 München (Germany). Telefax: Int code + (89) 5902 451
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  • Dipl.-Chem. Gunter Trojandt,

    1. Institut für Organische Chemie der Universität München (Germany)
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  • Dr. Kurt Polborn,

    1. Institut für Organische Chemie der Universität München (Germany)
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  • Prof. Dr. Wolfgang Steglich

    Corresponding author
    1. Institut für Organische Chemie der Universität München (Germany)
    • Institut für Organische Chemie der Universität München (Germany)
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  • Generous support by the Deutsche Forschungsgemeinschaft, the Fonds der Chemischen Industrie, and Studienstiftung des Deutschen Volkes is gratefully acknowledged.

  • Dedicated to Professor Rolf Huisgen on the occasion of his 75th birthday

Abstract

original image

Preorganization by intramolecular hydrogen bonds facilitates the synthesis of macrobicyclic TiIV complexes with ring sizes up to 32 atoms (shown schematically below). C3-symmetric peptide bundles, each fixed by a central nitrogen atom, serve as ligands. AS [DOUBLE BOND] α-amino acids (Gly, Leu, Phe, Val).

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