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Biosyntheses of Novel Emycins from the Mutant Strain Streptomyces cellulosae ssp. griseoincarnatus 1114-2

Authors

  • Dipl.-Chem. Martin Gerlitz,

    1. Institut für Organische Chemie der Universität, Tammannstrasse 2, D-37077 Göttingen (Germany) Telefax: Int code + (551)39-9660 e-mail: jrohr@gwdg.de
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  • Dipl.-Ing. Györgyi Udarnoki,

    1. Institut für Organische Chemie der Universität, Tammannstrasse 2, D-37077 Göttingen (Germany) Telefax: Int code + (551)39-9660 e-mail: jrohr@gwdg.de
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  • Priv.-Doz. Dr. Jürgen Rohr

    Corresponding author
    1. Institut für Organische Chemie der Universität, Tammannstrasse 2, D-37077 Göttingen (Germany) Telefax: Int code + (551)39-9660 e-mail: jrohr@gwdg.de
    • Institut für Organische Chemie der Universität Tammannstrasse 2, D-37077 Göttingen (Germany) Telefax: Int code + (551)39-9660 e-mail: jrohr@gwdg.de
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  • This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie. We thank the Hoechst AG, Frankfurt/Main, Germany, for the wild-type strain FH-S 1114.

Abstract

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Natural products such as 1 with unprecedented molecular frameworks are produced by the mutant 1114-2 of Streptomyces cellulosae ssp. griseoincarnatus (FH-S 1114). Biosynthetic investigations on this genetically modified strain show that the changes at the molecular level are caused mainly by the influence of an oxygenase. Moreover, an unusual rearrangement is also involved in the generation of the product palette.

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