Natural products such as 1 with unprecedented molecular frameworks are produced by the mutant 1114-2 of Streptomyces cellulosae ssp. griseoincarnatus (FH-S 1114). Biosynthetic investigations on this genetically modified strain show that the changes at the molecular level are caused mainly by the influence of an oxygenase. Moreover, an unusual rearrangement is also involved in the generation of the product palette.
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