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Keywords:

  • biotechnology;
  • chromatography;
  • dehydratases;
  • deoxycarbohydrates;
  • enzymes
Thumbnail image of graphical abstract

The enzymatic deoxygenation of dTDP-glucose and two 3-deoxy analogues [Eq. (a)] is now possible on a preparative scale with dTDP-D-glucose-4,6-dehydratase. In addition a highly selective HPLC method for the separation of structurally related activated sugars has been developed. This should provide new impetus for structure–function studies of deoxysugars and further elucidation of their biosynthetic pathways. R [DOUBLE BOND] OH, H, N3; dTDP = thymidine-5′-diphosphate.