Synthesis and Properties of First to Third Generation Dendrimers with Doubly and Triply Branched Chiral Building Blocks

Authors

  • Dipl.-Chem. Peter Murer,

    1. Laboratorium für Organische Chemie der Eidgenössischen Technischen Hochschule, ETH-Zentrum, Universitätstrasse 16, CH-8092 Zürich (Switzerland), Telefax: Int. code + (1)632-1144, e-mail: seebach@org.chem.ethz.ch
    Search for more papers by this author
  • Prof. Dr. Dieter Seebach

    Corresponding author
    1. Laboratorium für Organische Chemie der Eidgenössischen Technischen Hochschule, ETH-Zentrum, Universitätstrasse 16, CH-8092 Zürich (Switzerland), Telefax: Int. code + (1)632-1144, e-mail: seebach@org.chem.ethz.ch
    • Laboratorium für Organische Chemie der, Eidgenössischen Technischen Hochschule, ETH-Zentrum, Universitätstrasse 16, CH-8092 Zürich (Switzerland), Telefax: Int. code + (1)632-1144, e-mail: seebach@org.chem.ethz.ch
    Search for more papers by this author

  • Part of the proposed dissertation by P. Murer.

  • Dedicated to Professor Manfred Regitz on the occasion of his 60th birthday

Abstract

original image

Dendrimers with chiral branch components and chiral central units display remarkable CD effects. An interesting case of diastereoselectivity occurs in the synthesis of these compounds: The branch bromide 1 with (S) configuration at the four nonspecific centers can be coupled with the triol 2; the (R) branch bromide 1, on the other hand, cannot!

Ancillary