Enantioselective Reduction of Ketones with Sodium Borohydride, Catalyzed by Optically Active (β-Oxoaldiminato)cobalt(II) Complexes

Authors

  • Takushi Nagata,

    1. Basic Research Laboratories for Organic Synthesis, Mitsui Petrochemical Industries, Nagaura, Sodegaura-shi, Chiba 299-02 (Japan), Telefax: Int. code + 438/625395
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  • Dr. Kiyotaka Yorozu,

    1. Basic Research Laboratories for Organic Synthesis, Mitsui Petrochemical Industries, Nagaura, Sodegaura-shi, Chiba 299-02 (Japan), Telefax: Int. code + 438/625395
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  • Dr. Tohru Yamada,

    1. Basic Research Laboratories for Organic Synthesis, Mitsui Petrochemical Industries, Nagaura, Sodegaura-shi, Chiba 299-02 (Japan), Telefax: Int. code + 438/625395
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  • Prof. Dr. Teruaki Mukaiyama

    Corresponding author
    1. Department of Applied Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka, Shinjuku-ku, Tokyo 162 (Japan)
    • Department of Applied Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka, Shinjuku-ku, Tokyo 162 (Japan)
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  • Dedicated to Professor Ivar Ugi on the occasion of his 65th birthday

Abstract

original image

Asymmetric reduction of prochiral ketones with sodium borohydride proceeds in the presence of catalytic amounts of optically active β-oxoaldiminatocobalt(II) complexes 1 to the corresponding optically active secondary alcohols in high chemical yields with high enantioselectivities (68–94% ee).

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