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Keywords:

  • brain lipids;
  • neurotransmitters;
  • sphingosines
Thumbnail image of graphical abstract

Amide 1 is not the universal sleep-inducing substance, and no appropriate receptors have been found in the brain, but naturally occuring 1 does induce sleep. Compound 1 was found in the cerebrospinal fluid of sleep-deprived animals. Recent research on this compound and others with similar effects have led to a better understanding of the phenomenon of sleep, at least on a molecular level.