An angucycline antibiotic with a nonaromatic B ring, (+)-SF 2315A (3), was synthesized enantioselectively for the first time. A key transformation in the 23-step reaction sequence, which starts from (−)-quinic acid, is the stereocontrolled Diels-Alder reaction between diene 1 and bromojuglone 2. TIPS = triisopropylsilyl.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.