Design, Synthesis, and Ion-Transport Properties of a Novel Family of Cyclic, Adamantane-Containing Cystine Peptides

Authors


  • This work was supported financially by the Department of Science and Technology, New Delhi (India). We are most grateful to Prof. S. Ranganathan (RRL, Trivandrum) and Prof. D. Balasubramanian (CCMB, Hyderabad) for helpful advice and comments.

Abstract

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A one-step synthesis provided the cyclopeptides 1 – 4 (n = 2 – 5) composed of repeating adamantane and L-cystine units. These macrocycles assume a cavitand-like conformation, in which the interior is hydrophilic and the periphery hydrophobic. Consequently, they can transport Na+ and K+ ions selectively in model membranes.

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