Highly stereoselective, repetitive Diels–Alder reactions provide a route to novel molecular tweezers, which are excellently preorganized for the formation of complexes and for the self-assembly of side chains. Bond angle deformations, which require little energy, allow the tweezer arms to be expanded or compressed; thus, as receptors they can, to a certain extent, provide a geometrical fit to the structure of a potential substrate. The structure of a tweezer of this kind is shown schematically on the right.
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