Orthogonal Glycosylation Strategy for Rapid Assembly of Oligosaccharides on a Polymer Support


  • This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture and also by the Special Coordination Funds of the Science and Technology Agency of the Japanese Government. We thank Ms. M. Yoshida and her staff for elemental analyses, and Ms. A. Takahashi for technical assistance.


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Only a single purification step is required to isolate the glycoconjugate-related oligosaccharides prepared by a new strategy, which is shown schematically below. Prior to purification the support-bound oligosaccharide, which is labeled with a hydrophobic tag, is cleaved from the polymeric support and deprotected.