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Orthogonal Glycosylation Strategy for Rapid Assembly of Oligosaccharides on a Polymer Support†
Article first published online: 22 DEC 2003
DOI: 10.1002/anie.199625101
Copyright © 1996 by VCH Verlagsgesellschaft mbH, Germany
Issue
Angewandte Chemie International Edition in English
Volume 35, Issue 21, pages 2510–2512, November 18, 1996
Additional Information
How to Cite
Ito, Y., Kanie, O. and Ogawa, T. (1996), Orthogonal Glycosylation Strategy for Rapid Assembly of Oligosaccharides on a Polymer Support. Angewandte Chemie International Edition in English, 35: 2510–2512. doi: 10.1002/anie.199625101
- †
This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture and also by the Special Coordination Funds of the Science and Technology Agency of the Japanese Government. We thank Ms. M. Yoshida and her staff for elemental analyses, and Ms. A. Takahashi for technical assistance.
Publication History
- Issue published online: 22 DEC 2003
- Article first published online: 22 DEC 2003
- Manuscript Received: 21 MAY 1996
- Abstract
- References
- Cited By
Keywords:
- glycoproteins;
- glycosylations;
- oligosaccharides;
- solid-phase syntheses
Graphical Abstract
Only a single purification step is required to isolate the glycoconjugate-related oligosaccharides prepared by a new strategy, which is shown schematically below. Prior to purification the support-bound oligosaccharide, which is labeled with a hydrophobic tag, is cleaved from the polymeric support and deprotected.