Advertisement

A Novel Strategy towards the Total Synthesis of Cyclopeptide Alkaloids

Authors


Abstract

original image

Macrocyclization by ether formation (retrosynthesis shown below), the key step in a conceptually novel approach to cyclopeptide alkaloids, relies on an intramolecular nucleophilic substitution reaction. This new strategy was demonstrated for the synthesis of model compounds for the 14-membered cyclopeptide alkaloids, an important class of natural products.

Ancillary