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Keywords:

  • amino acids;
  • asymmetric synthesis;
  • chirality
Thumbnail image of graphical abstract

The repertoire for the synthesis of α-alkylated α-amino acids 1 is restricted, but constantly expanding. Since these amino acids are of interest for the construction of peptides with a fixed conformation, as ligands for enantioselective catalytic aldol reactions, and also from a pharmaceutical point of view, the development of simple methods to synthesize these important, nonproteinogenic amino acids is still a challenge for the synthetic chemist.