This research was supported by the National Institute of General Medical Sciences (GM 10265).
Stability and Conformational Switching in a Mini-Cyclic Oligonucleotide Conjugate†
Article first published online: 22 DEC 2003
Copyright © 1997 by VCH Verlagsgesellschaft mbH, Germany
Angewandte Chemie International Edition in English
Volume 36, Issue 6, pages 599–601, April 4, 1997
How to Cite
Herrlein, M. K. and Letsinger, R. L. (1997), Stability and Conformational Switching in a Mini-Cyclic Oligonucleotide Conjugate. Angew. Chem. Int. Ed. Engl., 36: 599–601. doi: 10.1002/anie.199705991
- Issue published online: 22 DEC 2003
- Article first published online: 22 DEC 2003
- Manuscript Received: 16 SEP 1996
- conformation dertermination;
A remarkably stable base-stacked structure is shown by the 70-membered ring 2, which possesses only four nucleotide bases and is formed by efficient cyclization of the oligonucleotide conjugate 1. In the presence of alkali, 2 twists to bring the stilbene groups into close proximity, as indicated by an excimer emission upon irradiation.