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Stability and Conformational Switching in a Mini-Cyclic Oligonucleotide Conjugate

Authors

  • Dr. Mathias K. Herrlein,

    1. Department of Chemistry, Northwestern University, Evanston, IL 60208 (USA), Fax: Int. code +(847) 491-7713
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  • Dr. Robert L. Letsinger

    Corresponding author
    1. Department of Chemistry, Northwestern University, Evanston, IL 60208 (USA), Fax: Int. code +(847) 491-7713
    • Department of Chemistry, Northwestern University, Evanston, IL 60208 (USA), Fax: Int. code +(847) 491-7713
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  • This research was supported by the National Institute of General Medical Sciences (GM 10265).

Abstract

original image

A remarkably stable base-stacked structure is shown by the 70-membered ring 2, which possesses only four nucleotide bases and is formed by efficient cyclization of the oligonucleotide conjugate 1. In the presence of alkali, 2 twists to bring the stilbene groups into close proximity, as indicated by an excimer emission upon irradiation.

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