Non-Biaryl Atropisomers: New Classes of Chiral Reagents, Auxiliaries, and Ligands?
Article first published online: 22 DEC 2003
Copyright © 1997 by VCH Verlagsgesellschaft mbH, Germany
Angewandte Chemie International Edition in English
Volume 36, Issue 9, pages 949–951, May 16, 1997
How to Cite
Clayden, J. (1997), Non-Biaryl Atropisomers: New Classes of Chiral Reagents, Auxiliaries, and Ligands?. Angew. Chem. Int. Ed. Engl., 36: 949–951. doi: 10.1002/anie.199709491
- Issue published online: 22 DEC 2003
- Article first published online: 22 DEC 2003
- asymmetric syntheses;
Commonly observed, but rarely exploited, is the restricted rotation about CC single bonds inherent in certain non-biaryl compounds. Recent examples of stereoselective reactions directed by atropisomeric amides (such as that shown below) point the way to a future for these compounds as tools for asymmetric synthesis.