Non-Biaryl Atropisomers: New Classes of Chiral Reagents, Auxiliaries, and Ligands?

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Abstract

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Commonly observed, but rarely exploited, is the restricted rotation about C[BOND]C single bonds inherent in certain non-biaryl compounds. Recent examples of stereoselective reactions directed by atropisomeric amides (such as that shown below) point the way to a future for these compounds as tools for asymmetric synthesis.

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