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Keywords:

  • amides;
  • asymmetric syntheses;
  • atropisomerism;
  • chirality;
  • isomerism
Thumbnail image of graphical abstract

Commonly observed, but rarely exploited, is the restricted rotation about C[BOND]C single bonds inherent in certain non-biaryl compounds. Recent examples of stereoselective reactions directed by atropisomeric amides (such as that shown below) point the way to a future for these compounds as tools for asymmetric synthesis.