Crystal Engineering of Melamine–Imide Complexes; Tuning the Stoichiometry by Steric Hindrance of the Imide Carbonyl Groups


  • The authors acknowledge the fruitful discussions with many colleagues at DSM Research and the University of Eindhoven. Dr. B. Coussens is acknowledged for her contributions in molecular modeling.


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A defined melamine–imide ratio in cocrystals can be selected by changing the steric hindrance around the hydrogen-bond acceptor sites of the imides. Crystalline 1:1, 1:2, and 1:3 complexes of melamine may thus be obtained with succinimide, glutarimide, and 1-N-propylthymine (see picture), respectively.