Intermediates in the Intermolecular, Asymmetric Heck Arylation of Dihydrofurans


  • We thank the EPSRC for postdoctoral support for K. K. H. and Johnson–Matthey for the loan of palladium salts. Dr. H. Doucet kindly helped with assays of enantiomeric purity.


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Double isomerization results in a Pd-alkyl compound with unexpected structure, which is stable until −40°, from the reaction of the Pd complex shown on the right with 2,3-dihydrofuran. The course of the asymmetric Heck reaction was followed by NMR spectroscopy.

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