We are grateful to the National Science Foundation and the National Institutes of Health (postdoctoral fellowship for J. K. L. 1F32GM17460-011) for financial support of this work. We also thank the San Diego Supercomputer Center and the National Center for Supercomputing Applications for computational facilities.
Cation-Cyclization Selectivity: Variable Structures of Protonated Cyclopropanes and Selectivity Control by Catalytic Antibodies†
Article first published online: 22 DEC 2003
Copyright © 1997 by VCH Verlagsgesellschaft mbH, Germany
Angewandte Chemie International Edition in English
Volume 36, Issue 9, pages 1003–1005, May 16, 1997
How to Cite
Lee, J. K. and Houk, K. N. (1997), Cation-Cyclization Selectivity: Variable Structures of Protonated Cyclopropanes and Selectivity Control by Catalytic Antibodies. Angew. Chem. Int. Ed. Engl., 36: 1003–1005. doi: 10.1002/anie.199710031
- Issue published online: 22 DEC 2003
- Article first published online: 22 DEC 2003
- Manuscript Received: 9 OCT 1996
- catalytic antibodies cations;
- molecular modeling;
- nonclassical structures
A nonclassical, protonated cyclopropane is the intermediate formed in an antibodycatalyzed cyclization reaction. The selectivity in favor of the cyclopropane product is increased upon binding of the catalytic antibody, which amplifies the inherent preference for one reaction pathway.