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Keywords:

  • acetylenosaccharides;
  • alkynes;
  • cyclodextrins;
  • host–guest chemistry;
  • structure elucidation
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An antiparallel arrangement of water-containing tubes characterizes the crystal structure of the cyclotetramer 1. The tetramer 1, which binds to D- and L-adenosine in aqueous solution, was prepared in four steps in a yield of 50% from a 1,4-dialkynylated glucose derivative; the corresponding cyclohexamer and cyclootamer were isolated as byproducts.