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Keywords:

  • aldol reactions;
  • asymmetric catalysis;
  • asymmetric synthesis;
  • homogeneous catalysis;
  • lanthanum
Thumbnail image of graphical abstract

Up to 94%ee can be achieved in the title reaction [Eq. (a)], which was previously only possible with enzymes. In this reaction LaLi3 tris(binaphthoxide) (LLB) imitates the function of enzymes by displaying both Lewis acidity and Brønsted basicity.