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Keywords:

  • asymmetric catalysis;
  • C[BOND]C coupling;
  • enantioselectivity;
  • Michael addition;
  • transition metals
Thumbnail image of graphical abstract

PdII-catalyzed Michael reactions of β-dicarbonyl compounds 1 and enones 2 can generate quaternary stereocenters (shown in yellow) with selectivities of 90 % ee at relatively high temperatures (−10 °C). This method represents a breakthrough in enantioselective synthesis.