Construction of Quaternary Stereocenters: New Perspectives through Enantioselective Michael Reactions

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Abstract

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PdII-catalyzed Michael reactions of β-dicarbonyl compounds 1 and enones 2 can generate quaternary stereocenters (shown in yellow) with selectivities of 90 % ee at relatively high temperatures (−10 °C). This method represents a breakthrough in enantioselective synthesis.

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