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Catalyst–Substrate Coimmobilization: A Strategy for Catalysts Discovery in Split-and-Mix Libraries


  • This work was supported by the BACHEM company and the Swiss National Science Foundation. H.W. is grateful to the Fonds der Chemischen Industrie for a Liebig Fellowship and an assistant professorship sponsored by the BACHEM company.


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Potentially applicable to any bimolecular reaction: A new method for the discovery of catalysts among the members of split-and-mix libraries is described. A reaction partner (A) is immobilized along with each library member (the potential catalyst) on the same bead. The reaction partner B is labeled with a dye, thus a reaction between A and B is easily visualized through the attachment of the marker to the beads that carry the active catalyst.