Sequence-Selective Molecular Recognition between β Sheets


  • We thank the NIH for grant support (GM-49076). D.M.C. thanks the Bill and Melinda Gates Foundation and the UCI Institute for Brain Aging and Dementia for a fellowship and training grant support (NIA-5T32AG000096).


original image

Molecular recognition between peptide β sheets is sequence selective! By simply controlling the placement of two threonine (Thr) or valine (Val) residues, peptides that preferentially form either homodimers or heterodimers with about tenfold selectivity can be generated. The picture shows the structure of a Thr–Val⋅Val–Thr heterodimer.