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Self-Assembled Monolayers That Transduce Enzymatic Activities to Electrical Signals


  • This work was supported by the National Science Foundation and the Materials Research Science and Engineering Center.


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A dynamic substrate that transduces a biological activity into an electrical signal has been developed (see scheme). The enzymatic conversion of a redox-inactive substrate presented at a self-assembled monolayer produced a redox-active product that is monitored electrochemically in real time.

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