Total Synthesis of Amphidinolide T4


  • Generous financial support by the Deutsche Forschungsgemeinschaft (Leibniz award to A.F.) and the Fonds der Chemischen Industrie is gratefully acknowledged.


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Organometallic chemistry in general and catalysis in particular are used in the first total synthesis of amphidinolide T4 (see scheme); a prototype member of a series of macrolide antibiotics of marine origin with rings containing an odd number of carbon atoms.