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Review
Highly Functionalized Organomagnesium Reagents Prepared through Halogen–Metal Exchange
Article first published online: 17 SEP 2003
DOI: 10.1002/anie.200300579
Copyright © 2003 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
1521-3773/asset/cover.gif?v=1&s=412bc65bdcb3f0e34a94f27c1c13e908726694d4 "Angewandte Chemie International Edition")
Angewandte Chemie International Edition
Volume 42, Issue 36, pages 4302–4320, September 22, 2003
Additional Information
How to Cite
Knochel, P., Dohle, W., Gommermann, N., Kneisel, F. F., Kopp, F., Korn, T., Sapountzis, I. and Vu, V. A. (2003), Highly Functionalized Organomagnesium Reagents Prepared through Halogen–Metal Exchange . Angew. Chem. Int. Ed., 42: 4302–4320. doi: 10.1002/anie.200300579
Publication History
- Issue published online: 17 SEP 2003
- Article first published online: 17 SEP 2003
- Manuscript Received: 7 FEB 2003
- Abstract
- Article
- References
- Cited By
Keywords:
- C
![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
C coupling; - Grignard reaction;
- magnesium;
- organometallic compounds;
- synthetic methods
Abstract
Organomagnesium reagents occupy a central position in synthetic organic and organometallic chemistry. Recently, the halogen–magnesium exchange has considerably extended the range of functionalized Grignard reagents available for synthetic purposes. Functional groups such as esters, nitriles, iodides, imines, or even nitro groups can be present in a wide range of aromatic and heterocyclic organomagnesium reagents. Also various highly functionalized alkenyl magnesium species can be prepared. These recent developments as well as new applications of organomagnesium reagents in cross-coupling reactions and amination reactions will be covered in this Review.