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Recent Developments in the Catalytic Asymmetric Synthesis of α- and β-Amino Acids


  • The author thanks Professor Run-Qiu Huang and Professor Zheng-Zhi Zhang for the helpful suggestions and criticisms. The author gratefully acknowledges Professor Qi-Lin Zhou's encouragement of his research work.


The stereoselective synthesis of amino acids is of great importance for the construction of optically active natural products and pharmaceuticals. Apart from enzymes, a broad repertoire of chiral reagents, auxiliaries, and catalysts can be used for the formation of amino acids. Asymmetric reactions using catalytic amounts of chiral molecules provide efficient methods for the generation of optically active proteinogenic and nonproteinogenic amino acids. This minireview collects recent work on catalytic asymmetric synthesis of α- and β-amino acids.