Increasing the Local Concentration of Drugs by Hydrogel Formation


  • The author thanks the Deutsche Forschungsgemeinschaft (Emmy-Noether-Programm) and the Fonds der Chemischen Industrie for financial support.


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Drugs that gel: The first hydrogel-forming drug, a pyrene-derivatized form of the antibiotic vancomycin (see structure), exhibits an 11-fold higher antimicrobial activity than vancomycin itself. A possible mechanism for this effect and its influence on future drug design are discussed.