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Keywords:

  • amino acids;
  • cycloaddition;
  • diastereoselectivity;
  • enantioselectivity;
  • Michael addition
Thumbnail image of graphical abstract

Unusual representatives of the synthetically attractive β-amino acids can be accessed by two novel synthetic routes. The synthesis of β2,3- and β2,3,3-amino acids (A and B, respectively) involves a diastereoselective 1,3-dipolar cycloaddition, whereas β2-amino acids C are obtained by enantioselective CuI-catalyzed conjugate addition of dialkyl zinc compounds to nitroalkenes.