The author thanks the Deutsche Forschungsgemeinschaft and Fonds der Chemischen Industrie for continuing financial support.
Supramolecular Drug-Delivery Systems Based on Polymeric Core–Shell Architectures†
Article first published online: 29 DEC 2003
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 43, Issue 3, pages 278–282, January 5, 2004
How to Cite
Haag, R. (2004), Supramolecular Drug-Delivery Systems Based on Polymeric Core–Shell Architectures. Angew. Chem. Int. Ed., 43: 278–282. doi: 10.1002/anie.200301694
- Issue published online: 29 DEC 2003
- Article first published online: 29 DEC 2003
- block copolymers;
- drug delivery;
- supramolecular chemistry
Hitting the target: Although the cellular uptake of supramolecular nanocarriers by endocytosis is not cell-specific, a high passive selectivity has been observed in porous tissues, such as tumor tissue. The encapsulated, often toxic, drug is efficiently shielded and can develop its activity by selective release from the nanocarrier upon a shift of the pH value in the tumor tissue or inside the cell (see scheme).