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Keywords:

  • atom economy;
  • cyclization;
  • enantioselectivity;
  • palladium;
  • rhodium;
  • ruthenium
Thumbnail image of graphical abstract

Highly functionalized carbo- and heterocycles can be prepared enantioselectively from simple enynes in transition-metal-catalyzed reactions. This versatile, atom-economic, and environmentally friendly approach has become a mainstay in natural product synthesis. The concise synthesis of (+)-pilocarpine is one example (see scheme). binap=2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl), cod=cyclooctadiene, RT=room temperature.