Get access

Asymmetric Cycloisomerization of 1,6- and 1,7-Enynes by Transition-Metal Catalysts



original image

Highly functionalized carbo- and heterocycles can be prepared enantioselectively from simple enynes in transition-metal-catalyzed reactions. This versatile, atom-economic, and environmentally friendly approach has become a mainstay in natural product synthesis. The concise synthesis of (+)-pilocarpine is one example (see scheme). binap=2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl), cod=cyclooctadiene, RT=room temperature.

Get access to the full text of this article