We acknowledge financial support from NSF (CHE-0208930). W.L. is an Alfred P. Sloan Fellow, an Arnold and Mabel Beckman Young Investigator, a Cottrell Scholar of Research Corp, and a Camille Dreyfus Teacher-Scholar.
Chiral, Porous, Hybrid Solids for Highly Enantioselective Heterogeneous Asymmetric Hydrogenation of β-Keto Esters†
Article first published online: 10 DEC 2003
Copyright © 2003 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 42, Issue 48, pages 6000–6003, December 15, 2003
How to Cite
Hu, A., Ngo, H. L. and Lin, W. (2003), Chiral, Porous, Hybrid Solids for Highly Enantioselective Heterogeneous Asymmetric Hydrogenation of β-Keto Esters. Angew. Chem. Int. Ed., 42: 6000–6003. doi: 10.1002/anie.200351264
- Issue published online: 10 DEC 2003
- Article first published online: 10 DEC 2003
- Manuscript Revised: 10 JUN 2003
- Manuscript Received: 24 FEB 2003
- asymmetric catalysis;
- hybrid materials;
- supported catalysts;
Catalytic building blocks: Chiral porous zirconium phosphonates containing Ru-binap moieties are synthesized by a molecular building-block approach, and characterized by a variety of techniques. These hybrid solids are used for enantioselective heterogeneous asymmetric hydrogenation of β-keto esters with ee values of up to 95 % (see picture). Ready tunability of such a molecular building-block approach promises to lead to useful heterogeneous asymmetric catalysts.