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Toward Waste-Free Production of Heck Products with a Catalytic Palladium System under Oxygen


  • This work was supported by the Belgian Federal Government within the framework of an IAP program for supramolecular catalysis. M.D. is a research assistant of FWO (Belgium).


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A 100 % carbon-efficient, halide- and solvent-free alternative for the synthesis of Heck-type products is the direct oxidative coupling of arenes with olefins, catalyzed by Pd(OAc)2 under oxygen (see scheme). The reactions can be performed under mild conditions, and water is the only by-product. (TON=turnover number, TOF=turnover frequency.)