We thank NWO-ZonMw for a STIGON grant. Prof. J. C. M. van Hest, Dr. F. L. van Delft, and Prof. R. J. M. Nolte are thanked for their helpful comments. Dr. D. de Vos (Pharmachemie B.V., Haarlem, The Netherlands) is acknowledged for a gift of paclitaxel. We are grateful to Dr. H. Engelkamp for assistance in preparing Figures 1 and 2.
“Cascade-Release Dendrimers” Liberate All End Groups upon a Single Triggering Event in the Dendritic Core†
Article first published online: 1 SEP 2003
Copyright © 2003 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 42, Issue 37, pages 4490–4494, September 29, 2003
How to Cite
de Groot, F. M. H., Albrecht, C., Koekkoek, R., Beusker, P. H. and Scheeren, H. W. (2003), “Cascade-Release Dendrimers” Liberate All End Groups upon a Single Triggering Event in the Dendritic Core. Angew. Chem. Int. Ed., 42: 4490–4494. doi: 10.1002/anie.200351942
- Issue published online: 25 SEP 2003
- Article first published online: 1 SEP 2003
- Manuscript Revised: 10 JUL 2003
- Manuscript Received: 21 MAY 2003
- drug delivery;
- multiple release;
A single triggering event in the core of a dendrimer composed of two or more generations of multiple-release monomeric building blocks can induce the release of all end groups at the termini of the dendrimer (see schematic representation). Such multiple-release systems could find application, for example, in the field of (targeted) drug delivery, where a disease- or organ-specific activation event could trigger simultaneous release of multiple biologically active molecules.