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Keywords:

  • dendrimers;
  • drug delivery;
  • fragmentation;
  • multiple release;
  • prodrugs
Thumbnail image of graphical abstract

A single triggering event in the core of a dendrimer composed of two or more generations of multiple-release monomeric building blocks can induce the release of all end groups at the termini of the dendrimer (see schematic representation). Such multiple-release systems could find application, for example, in the field of (targeted) drug delivery, where a disease- or organ-specific activation event could trigger simultaneous release of multiple biologically active molecules.