Catalytic Enantioselective Conjugate Reduction of β,β-Disubstituted Nitroalkenes


  • This research was supported by Sumika Fine Chemicals, Japan. C.C. was supported by a fellowship of the Fonds der Chemischen Industrie (Germany).


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Efficient addition: Bisphosphane–CuI complexes catalyze the enantioselective reduction of β,β-disubstituted nitroalkenes, giving chiral β,β-disubstituted nitroalkanes in useful yields and selectivities (see scheme). The reaction can be carried out with as little as 0.1 mol % of complex, rendering the process among one of the more efficient methods for conjugate addition chemistry.