Highly Sensitive Recognition of Substrates of Adrenergic Receptors at the Air/Water Interface


  • We gratefully acknowledge support by the Deutsche Forschungsgemeinschaft (DFG SCHR 604/1-3).


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Almost like the real thing: Amphiphilic properties ensure that an artificial adrenaline receptor can be embedded in lipid monolayers just like the natural example. Here it forms large domains by self-assembly, which were investigated by Langmuir–Blodgett techniques. Embedded, the macrocyclic receptor is much more sensitive and selective than in solution. Monolayers containing receptor molecules can distinguish between adrenergic receptor substrates with similar structures.