Potential Peptide Carriers: Amphipathic Proline-Rich Peptides Derived from the N-Terminal Domain of γ-Zein

Authors

  • Jimena Fernández-Carneado Dr.,

    1. Institut de Recerca Biomèdica de Barcelona, Parc Científic de Barcelona, Josep Samitier 1, 08028 Barcelona, Spain, and, Departament de Química Orgànica, Universitat de Barcelona, Martí i Franqués 1, 08028 Barcelona, Spain, Fax:(+34) 93-403-7126
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  • Marcelo J. Kogan Dr.,

    1. Institut de Recerca Biomèdica de Barcelona, Parc Científic de Barcelona, Josep Samitier 1, 08028 Barcelona, Spain, and, Departament de Química Orgànica, Universitat de Barcelona, Martí i Franqués 1, 08028 Barcelona, Spain, Fax:(+34) 93-403-7126
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  • Susanna Castel Dr.,

    1. Microscopia Confocal i Manipulació Cellular, SCT Universitat de Barcelona, Josep Samitier, 1, 08028 Barcelona, Spain
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  • Ernest Giralt Prof.

    1. Institut de Recerca Biomèdica de Barcelona, Parc Científic de Barcelona, Josep Samitier 1, 08028 Barcelona, Spain, and, Departament de Química Orgànica, Universitat de Barcelona, Martí i Franqués 1, 08028 Barcelona, Spain, Fax:(+34) 93-403-7126
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  • The authors acknowledge financial support from the EU (QLK2-CT-2001-01451), MCYT-FEDER (Bio2002-2301), and Generalitat de Catalunya (CeRBa and SGR).

Abstract

original image

Breaking into cells: A new family of peptides based on the amphipathic proline-rich sequence (VXLPPP)n, where n=1–3 and X=His, Lys, or Arg, has been designed (see picture). Their nonviral origin, absence of toxicity at high concentrations, and high solubility in water make this new series very promising for use in drug delivery.

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