Iron-Catalyzed Asymmetric Sulfide Oxidation with Aqueous Hydrogen Peroxide


  • We are grateful to the Fonds der Chemischen Industrie and to the Deutsche Forschungsgemeinschaft (DFG) within the SFB 380 “Asymmetric Synthesis by Chemical and Biological Methods” for financial support. We thank the Alexander von Humboldt Foundation for a postdoctoral fellowship (J.L.).


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An iron in the fire: Iron-based catalysts promote the asymmetric oxidation of alkyl aryl sulfides to the corresponding sulfoxides with up to 90 % ee (see scheme). Simple hydrogen peroxide (30 % in water) serves as the terminal oxidant.