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Asymmetric Direct Aldol Reaction Assisted by Water and a Proline-Derived Tetrazole Catalyst


  • We thank H. Ishibashi (Nagoya) and Dr. K. Yoza (Bruker, AXS) for performing X-ray single-crystal analyses, and Professor A. Yamamoto and N. Tamura (JST) for their support and valuable advice. This work was supported by SORST and by the Japan Science and Technology Corporation (JST).


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Just add water to improve the performance of direct aldol reactions like that shown. Previously, aldehydes with high water-affinity or -solubility were considered unsuitable for asymmetric synthesis.