We thank Mark Nilges and Joshua Telser for experimental assistance and valuable discussions regarding EPR. J.J.W. appreciates the generous support provided by an Arnold and Mabel Beckman Foundation Young Investigator Award, a National Science Foundation Faculty Early Career Development (CAREER) Award, and an Alfred P. Sloan Foundation Research Fellowship.
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Communication
Metal-Mediated Cross-Linking in the Generation of a Marine-Mussel Adhesive†
Article first published online: 18 DEC 2003
DOI: 10.1002/anie.200352759
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Sever, M. J., Weisser, J. T., Monahan, J., Srinivasan, S. and Wilker, J. J. (2004), Metal-Mediated Cross-Linking in the Generation of a Marine-Mussel Adhesive. Angewandte Chemie International Edition, 43: 448–450. doi: 10.1002/anie.200352759
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Publication History
- Issue published online: 14 JAN 2004
- Article first published online: 18 DEC 2003
- Manuscript Revised: 10 OCT 2003
- Manuscript Received: 1 SEP 2003
Keywords:
- bioinorganic chemistry;
- functional materials;
- peptidomimetics;
- proteins;
- transition metals
Graphical Abstract
Iron muscles into mussels: Marine mussels adhere to rocks with a protein-based glue. An iron complex is the key curing agent in this adhesive, and the iron center is coordinated by three DOPA residues (see picture). These studies present the first identified case in which a transition-metal center is integral to forming a noncrystalline biological material.