An Easy and Scalable Method for the Partial Alignment of Organic Molecules for Measuring Residual Dipolar Couplings

Authors

  • Burkhard Luy Dr.,

    1. Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, 85 747 Garching, Germany, Fax: (+49) 89-289-13210
    Search for more papers by this author
  • Kyryl Kobzar Dipl.-Chem.,

    1. Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, 85 747 Garching, Germany, Fax: (+49) 89-289-13210
    Search for more papers by this author
  • Horst Kessler Prof. Dr.

    1. Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, 85 747 Garching, Germany, Fax: (+49) 89-289-13210
    Search for more papers by this author

  • B.L. and H.K. acknowledge the Fonds der Chemischen Industrie and the DFG (Emmy-Noether-fellowships LU 835/1-1, KC 147/35) for financial support. We thank Prof. Dr.-Ing O. Nuyken, Dr. R. Jordan, Dr. M. Zweckstetter, Dr. R. Marx, O. Hiltner, and W. Günther for their help.

Abstract

original image

Stretched polystyrene gel (see picture) induces partial alignment of small molecules in an organic solvent for the measurement of residual dipolar couplings in high-resolution NMR spectroscopy. The degree of orientation can be varied over a wide range by the amount of cross-linking of the polymer. An important NMR parameter can thus be measured routinely.

Ancillary