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Abyssomicin C—A Polycyclic Antibiotic from a Marine Verrucosispora Strain as an Inhibitor of the p-Aminobenzoic Acid/Tetrahydrofolate Biosynthesis Pathway

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  • The work of R.D.S. has been supported by an Emmy Noether Fellowship for young investigators of the Deutsche Forschungsgemeinschaft (DFG) (SU 239/2-1) and the DFG-Forschergruppe (SU 239/1-1 and 1-2). We thank Prof. H.-J. Meyer for support in X-ray analyses and Prof. M. E. Maier for helpful discussions.

Abstract

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Plumbing the depths: Abyssomicin C (structure shown) from ocean floor sediment is a novel antibiotic that inhibits the biosynthesis steps between chorismate and p-aminobenzoic acid. Its activity may be explained by the irreversible trapping of the targeted enzymes by a Michael addition. Blocking the biosynthesis of p-aminobenzoic acid may be one approach to developing new antibiotics.

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