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Excess Electron Transport Through DNA: A Single Electron Repairs More than One UV-Induced Lesion


  • We thank the Swiss National Science Foundation (NCCR), the German Science Foundation, the Volkswagen Foundation, and the Fonds der Chemischen Industrie. T.C. is grateful for a Kékulé stipend.


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Site-selective injection of a single electron into thymine (yellow) through the modified nucleoside 1 (12) was used to examine the dependence of excess electron transfer in DNA on distance. The DNA was cleaved upon arrival of the electron at a thymine dimer (red). This assay showed that one electron can repair more than one UV-induced lesion in DNA 3.