We thank the NSF (CHE 0213522) for financial support, and Takasago for a research assistantship to H.S. We are also indebted to Dr. Takao Saito (Takasago), Drs. Rudolf Schmid and Michelangelo Scalone (Roche), Drs. Hans-Ulrich Blaser and Marc Thommen (Solvias) for supplying the SEGPHOS, BIPHEP, and JOSIPHOS ligands, respectively, used in this study.
Copper(I)-Catalyzed Asymmetric Hydrosilylations of Imines at Ambient Temperatures†
Article first published online: 16 FEB 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 43, Issue 17, pages 2228–2230, April 19, 2004
How to Cite
Lipshutz, B. H. and Shimizu, H. (2004), Copper(I)-Catalyzed Asymmetric Hydrosilylations of Imines at Ambient Temperatures. Angew. Chem. Int. Ed., 43: 2228–2230. doi: 10.1002/anie.200353294
- Issue published online: 16 APR 2004
- Article first published online: 16 FEB 2004
- Manuscript Received: 10 NOV 2003
- P ligands;
Are you looking for an operationally simple means of preparing enantio-enriched benzylic-like centers bearing nitrogen? Consider this new and convenient alternative to asymmetric hydrogenation: CuH when ligated by an enantiopure SEGPHOS ligand can catalytically reduce aryl ketimines at room temperature in high yields and even higher ee values (see scheme; TMDS=tetramethyldisiloxane).