This work was funded by the Cancer Research and Prevention Foundation. Additional support was provided to J.J.W. by an Alfred P. Sloan Foundation Research Fellowship.
1521-3773/asset/2002_left.gif?v=1&s=ac6b0d94a94d7ce7a210002b8096b42feffc0bcf)
1521-3773/asset/2002_right.gif?v=1&s=451042aa3415ae3ad0729984d26dee1866aca82e)
Communication
Inorganic Oxo Compounds React with Alkylating Agents: Implications for DNA Damage†
Article first published online: 16 JUN 2004
DOI: 10.1002/anie.200353363
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Hamilton, E. E. and Wilker, J. J. (2004), Inorganic Oxo Compounds React with Alkylating Agents: Implications for DNA Damage. Angew. Chem. Int. Ed., 43: 3290–3292. doi: 10.1002/anie.200353363
- †
Publication History
- Issue published online: 16 JUN 2004
- Article first published online: 16 JUN 2004
- Manuscript Revised: 8 MAR 2004
- Manuscript Received: 19 NOV 2003
Keywords:
- antitumor agents;
- bioinorganic chemistry;
- DNA alkylation;
- DNA damage;
- vanadium
Intercepting Carcinogens: The cancer-preventing properties of inorganic species, such as selenium and vanadium, are well known, but mechanistic understanding is scant. It is shown that inorganic oxo species (e.g., [SeO4]2−, [VO4]3−) can prevent DNA alkylation as well as detoxify alkylating agents by promoting hydrolysis to relatively harmless alcohols (see scheme).