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Remarkable 4,4′-Substituent Effects on Binap: Highly Enantioselective Ru Catalysts for Asymmetric Hydrogenation of β-Aryl Ketoesters and Their Immobilization in Room-Temperature Ionic Liquids


  • We acknowledge financial support from the NSF (CHE-0208930) as well as Dr. J. Johnson for access to his SFC equipment. W.L. is an Alfred P. Sloan Fellow, an Arnold and Mabel Beckman Young Investigator, a Cottrell Scholar of Research Corp, and a Camille Dreyfus Teacher–Scholar.


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A family of chiral diphosphanes with systematically tunable electronic and steric properties have been used in the asymmetric hydrogenation of β-aryl ketoesters with excellent ee values (up to 99.8 %) by taking advantage of remarkable 4,4′-substituent effects on binap. These highly enantioselective Ru catalysts have also been effectively immobilized in room-temperature ionic liquids (RTIL).