This work was supported by NSF CAREER Award, Office of Naval Research Young Investigator Award (N00014-03-10482), Searle Scholars Program, and by Dreyfus New Faculty Award. We thank Professors G. M. Whitesides, C. Chen, C. Hall, T. Van Ha, V. Turitto, and M. LaBarbera for invaluable suggestions.
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Minimal Functional Model of Hemostasis in a Biomimetic Microfluidic System†
Article first published online: 24 FEB 2004
DOI: 10.1002/anie.200353428
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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How to Cite
Runyon, M. K., Johnson-Kerner, B. L. and Ismagilov, R. F. (2004), Minimal Functional Model of Hemostasis in a Biomimetic Microfluidic System. Angewandte Chemie International Edition, 43: 1531–1536. doi: 10.1002/anie.200353428
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Publication History
- Issue published online: 9 MAR 2004
- Article first published online: 24 FEB 2004
- Manuscript Received: 28 NOV 2003
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Keywords:
- autocatalysis;
- biomimetic synthesis;
- hemostasis;
- microfluidic systems;
- self-repairing systems
Graphical Abstract
The proof of the model is in the function: A minimal model of hemostasis (a complex biochemical network responsible for blood coagulation) may be implemented with only three chemical reactions, which creates a biomimetic functional microfluidic system that is capable of repairing itself (as modeled in the figure). This simple system shows threshold response and sensitivity to flow similar to that observed in hemostasis.